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. 2024 Jul 18;65(9):100599. doi: 10.1016/j.jlr.2024.100599

Fig. 4.

Fig. 4

Zone-specific perturbations of hepatic lipids alteration in control and MASH. A: Box plots illustrating the zone-specific alteration of lipids across the liver zonation in control and MASH livers, including PI(36:4), PA(18:1_22:6), PE(16:0_22:6), PG(18:1_22:6), DAG(18:0_18:0), PE(16:1_22:6), PS(16:0_16:0) and PC(30:2). B: Ion images displaying the spatial distribution of PA(18:1_22:6), PE(16:0_22:6), and PC(30:2) in control and MASH samples. In this figure, the H&E staining images of the control and MASH groups are derived from the same H&E staining of the same samples as Fig. 3E. These images are reused across figures due to their representation of consistent staining results for comparative analysis. #P-value < 0.05, ##P-value < 0.01, ###P-value < 0.001 and ####P-value < 0.0001 the MASH compared with the control, ∗P-value < 0.05, ∗∗∗P-value < 0.001 and ∗∗∗∗P-value < 0.0001 the pericentral areas of each group compared with the periportal areas.