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Substitutions in helix I of the CP
| Genotype | Plaque phenotypea | NC accumulation (%)b |
|---|---|---|
| Wild type | lp | 100 |
| CP(L45W) | mp | 35 |
| CP(L45I) | mp | <2 |
| CP(L45C) | mp | <2 |
| CP(L45K) | sp | <2 |
| CP(L45E) | sp | <2 |
| CP(L45F) | sp | <2 |
| CP(L45A) | sp | <2 |
| CP(L45V) | sp | <2 |
| CP(L52D) | sp | <2 |
Determined by plaque assay in BHK cells 48 h posttransfection. lp, large plaque (3.0 to 3.5 mm); mp, medium plaque (2.5 to 3.0 mm); sp, small plaque (1.5 to 2.5 mm).
Determined at 12 h after electroporation of in vitro-transcribed RNA.
