Table 4.
Association of quartile percentages of serum fatty acids with all-cause mortality in different gender population
| All-cause mortality | All | Male | Female | P for interaction | |||
|---|---|---|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | ||
| Unsaturated fatty acids (N = 3719) | |||||||
| Myristoleic acid (14:1 n-5) | 0.123 | ||||||
| Q1 (< 3.34) | 1 (ref) | 1 (ref) | 1 (ref) | ||||
| Q2 (3.34–5.99) | 0.921 (0.674–1.260) | 0.607 | 0.995 (0.682–1.451) | 0.977 | 0.867 (0.495–1.518) | 0.617 | |
| Q3 (6.00-9.99) | 1.101 (0.813–1.490) | 0.534 | 0.973 (0.662–1.431) | 0.889 | 1.451 (0.878–2.398) | 0.146 | |
| Q4 (≥ 10.00) | 0.905 (0.662–1.236) | 0.529 | 0.629 (0.414–0.956) | 0.030 | 1.515 (0.921–2.491) | 0.102 | |
| Palmitoleic acid (16:1 n-7) | |||||||
| Q1 (< 135) | 1 (ref) | 1 (ref) | 1 (ref) | 0.030 | |||
| Q2 (135–198) | 1.351 (0.964–1.895) | 0.081 | 1.487 (1.008–2.195) | 0.046 | 1.404 (0.707–2.787) | 0.332 | |
| Q3 (199–297) | 1.507 (1.083–2.098) | 0.015 | 1.213 (0.803–1.834) | 0.359 | 2.707 (1.458–5.026) | 0.002 | |
| Q4 (≥ 298) | 1.581 (1.140–2.193) | 0.006 | 1.085 (0.716–1.645) | 0.699 | 3.275 (1.779–6.030) | <0.001 | |
| cis-Vaccenic acid (18:1 n-7) | |||||||
| Q1 (< 115) | 1 (ref) | 1 (ref) | 1 (ref) | <0.001 | |||
| Q2 (115–140) | 1.319 (0.926–1.878) | 0.125 | 1.195 (0.787–1.814) | 0.403 | 1.736 (0.884–3.410) | 0.109 | |
| Q3 (141–176) | 1.488 (1.050–2.107) | 0.025 | 1.240 (0.816–1.883) | 0.313 | 2.273 (1.186–4.358) | 0.013 | |
| Q4 (≥ 177) | 2.125 (1.555–2.978) | <0.001 | 1.216 (0.808–1.831) | 0.348 | 5.113 (2.812–9.297) | <0.001 | |
| Nervonic acid (24:1 n-9) | |||||||
| Q1 (< 73.0) | 1 (ref) | 1 (ref) | 1 (ref) | 0.073 | |||
| Q2 (73.0-86.2) | 0.977 (0.712–1.340) | 0.886 | 0.866 (0.596–1.259) | 0.451 | 1.487 (0.801–2.759) | 0.209 | |
| Q3 (86.3-101.9) | 0.997 (0.725–1.370) | 0.985 | 0.986 (0.667–1.457) | 0.943 | 1.471 (0.807–2.680) | 0.208 | |
| Q4 (≥ 102.0) | 1.165 (0.861–1.577) | 0.323 | 1.059 (0.706–1.588) | 0.783 | 2.026 (1.159–3.539) | 0.013 | |
| Eicosatrienoic acid (20:3 n-9) | |||||||
| Q1 (< 5.00) | 1(ref) | 1 (ref) | 1 (ref) | 0.318 | |||
| Q2 (5.00-6.99) | 1.207 (0.846–1.722) | 0.300 | 1.332 (0.855–2.074) | 0.205 | 0.937 (0.511–1.717) | 0.833 | |
| Q3 (7.00-9.44) | 1.598 (1.140–2.240) | 0.007 | 1.443 (0.931–2.236) | 0.101 | 1.768 (1.040–3.006) | 0.035 | |
| Q4 (≥ 9.44) | 2.044 (1.479–2.824) | <0.001 | 1.559 (1.020–2.385) | 0.040 | 2.742 (1.663–4.521) | <0.001 | |
| Docosatetraenoic acid (22:4 n-6) | |||||||
| Q1 (< 20.0) | 1 (ref) | 1 (ref) | 1 (ref) | 0.004 | |||
| Q2 (20.0-25.2) | 1.180 (0.837–1.665) | 0.344 | 1.117 (0.740–1.685) | 0.598 | 1.280 (0.684–2.396) | 0.440 | |
| Q3 (25.3–32.4) | 1.511 (1.086–2.102) | 0.014 | 1.008 (0.664–1.530) | 0.970 | 2.673 (1.522–4.696) | <0.001 | |
| Q4 (≥ 32.5) | 1.652 (1.195–2.285) | 0.002 | 0.987 (0.656–1.487) | 0.951 | 3.292 (1.891–5.734) | <0.001 | |
| Docosapentaenoic acid (22:5 n-6) | |||||||
| Q1 (< 15.0) | 1 (ref) | 1 (ref) | 1 (ref) | 0.427 | |||
| Q2 (15.0-19.6) | 0.863 (0.620–1.199) | 0.379 | 0.945 (0.631–1.414) | 0.783 | 0.794 (0.448–1.408) | 0.430 | |
| Q3 (19.7–25.8) | 1.185 (0.873–1.608) | 0.276 | 1.015 (0.688–1.496) | 0.941 | 1.533 (0.928–2.534) | 0.095 | |
| Q4 (≥ 25.9) | 1.190 (0.876–1.617) | 0.265 | 1.068 (0.717–1.590) | 0.748 | 1.519 (0.928–2.486) | 0.097 | |
| Docosahexaenoic acid (22:6 n-3) | |||||||
| Q1 (< 109) | 1 (ref) | 1 (ref) | 1 (ref) | 0.233 | |||
| Q2 (109–143) | 0.820 (0.593–1.132) | 0.227 | 0.750 (0.502–1.121) | 0.161 | 1.121 (0.637–1.975) | 0.692 | |
| Q3 (144–198) | 1.065 (0.790–1.437) | 0.679 | 0.982 (0.677–1.425) | 0.926 | 1.469 (0.864–2.498) | 0.155 | |
| Q4 (≥ 199) | 0.970 (0.714–1.318) | 0.846 | 0.936 (0.630–1.391) | 0.745 | 1.354 (0.800-2.291) | 0.259 | |
| Saturated fatty acids (N = 3900) | |||||||
| Palmitic acid (16:0) | |||||||
| Q1 (< 2159) | 1 (ref) | 1 (ref) | 1 (ref) | 0.142 | |||
| Q2 (2160–2629) | 1.173 (0.856–1.607) | 0.320 | 0.970 (0.667–1.410) | 0.873 | 2.099 (1.123–3.921) | 0.020 | |
| Q3 (2630–3229) | 1.184 (0.865–1.621) | 0.291 | 0.785 (0.530–1.162) | 0.227 | 2.801 (1.533–5.121) | <0.001 | |
| Q4 (≥ 3230) | 1.331 (0.979–1.808) | 0.068 | 0.764 (0.518–1.126) | 0.174 | 3.609 (1.998–6.520) | <0.001 | |
| Tricosanoic acid (23:0) | |||||||
| Q1 (< 23.3) | 1(ref) | 1(ref) | 1 (ref) | 0.620 | |||
| Q2 (23.3–27.9) | 0.691 (0.513–0.930) | 0.015 | 0.461 (0.310–0.684) | <0.001 | 0.807 (0.474–1.376) | 0.432 | |
| Q3 (28-32.9) | 0.730 (0.539–0.989) | 0.042 | 0.542 (0.354–0.830) | 0.005 | 0.947 (0.581–1.543) | 0.826 | |
| Q4 (≥ 33.0) | 0.724 (0.528–0.992) | 0.045 | 0.572 (0.402–0.815) | 0.002 | 0.852 (0.531–1.368) | 0.507 | |
| Lignoceric acid (24:0) | |||||||
| Q1 (< 46.8) | 1 (ref) | 1 (ref) | 1 (ref) | 0.170 | |||
| Q2 (46.8–54.9) | 0.705 (0.534–0.931) | 0.014 | 0.500 (0.348–0.718) | <0.001 | 1.295 (0.814–2.062) | 0.275 | |
| Q3 (55.0-64.9) | 0.451 (0.332–0.613) | <0.001 | 0.333 (0.224–0.496) | <0.001 | 0.792 (0.477–1.316) | 0.368 | |
| Q4 (≥ 65.0) | 0.569 (0.427–0.758) | <0.001 | 0.365 (0.246–0.541) | <0.001 | 1.153 (0.726–1.831) | 0.546 | |
Abbreviations Q1, below 25th percentile; Q2, between 25th percentile and 50th percentile; Q3, between 50th percentile and 75th percentile; Q4, above 75th percentile; HR, hazard ratio; CI, confidence interval; ref, reference