Table 2.
Antidepressants dispensed to residents aged ≥ 18 years in 2012 and 2019
| Second quarter 2012 | Second quarter 2019 | Relative risk 2019 vs 2012 (95% CI) | ||
|---|---|---|---|---|
| No. of patients (crude %) | No. of patients (crude %, age-sex standardiseda %) | |||
| Crude | Age-sex stand | |||
| Use of any antidepressant in population | ||||
| Total | 73,600/614,421 (12.0) | 92,601/607,215 (15.3; 15.2) | 1.27 (1.26–1.28) | 1.27 (1.26–1.28) |
| Single AD | 67,688/614,421 (11.0) | 82,900/607,215 (13.7; 13.6) | 1.24 (1.23–1.25) | 1.24 (1.23–1.25) |
| ≥ 2 ADs | 5912/614,421 (1.0) | 9701/607,215 (1.6; 1.6) | 1.66 (1.61–1.71) | 1.67 (1.62–1.72) |
| Sex | ||||
| Women | 51,083/315,046 (16.2) | 62,556/310,363 (20.2; 20.1) | 1.24 (1.23–1.26) | 1.24 (1.23–1.26) |
| Men | 22,517/299,375 (7.5) | 30,045/296,852 (10.1; 10.1) | 1.35 (1.32–1.37) | 1.34 (1.32–1.36) |
| Age groups (years) | ||||
| 18–39 | 14,179/191,155 (7.4) | 20,831/186,719 (11.2; 11.1) | 1.50 (1.47–1.53) | 1.49 (1.46–1.52) |
| 40–64 | 36,965/269,912 (13.7) | 44,493/252,871 (17.6; 17.5) | 1.28 (1.27–1.30) | 1.28 (1.27–1.30) |
| 65–79 | 15,710/111,195 (14.1) | 19,310/121,229 (16.0; 16.0) | 1.13 (1.11–1.15) | 1.13 (1.11–1.16) |
| ≥ 80 | 6746/42,159 (16.0) | 7967/46,396 (17.2; 17.4) | 1.07 (1.04–1.11) | 1.09 (1.05–1.12) |
| Type of antidepressant drug class | ||||
| SSRI | 39,791/614,421 (6.5) | 51,244/607,215 (8.4; 8.5) | 1.30 (1.29–1.32) | 1.32 (1.30–1.34) |
| TCA | 25,198/614,421 (4.1) | 25,833/607,215 (4.3; 4.2) | 1.04 (1.02–1.06) | 1.02 (1.00–1.03) |
| SNRI | 5092/614,421 (0.8) | 9470/607,215 (1.6; 1.6) | 1.88 (1.82–1.95) | 1.89 (1.83–1.96) |
| NASSA | 6865/614,421 (1.1) | 13,279/607,215 (2.2; 2.2) | 1.96 (1.90–2.01) | 1.95 (1.89–2.00) |
| MAOI | 160/614,421 (0.0) | 128/607,215 (0.0; 0.0) | 0.81 (0.64–1.02) | 0.81 (0.64–1.02) |
| Others | 2586/614,421 (0.4) | 2700/607,215 (0.4; 0.4) | 1.06 (1.00–1.11) | 1.04 (0.99–1.10) |
| Deprivation quintileb | ||||
| 1 (most deprived) | 15,599/95,057 (16.4) | 20,109/95,467 (21.1; 21.0) | 1.28 (1.26–1.31) | 1.28 (1.25–1.30) |
| 2 | 15,120/106,030 (14.3) | 19,099/104,903 (18.2; 18.2) | 1.28 (1.25–1.30) | 1.27 (1.25–1.30) |
| 3 | 13,594/114,450 (11.9) | 16,890/112,059 (15.1; 15.1) | 1.27 (1.24–1.30) | 1.27 (1.24–1.30) |
| 4 | 16,065/154,800 (10.4) | 19,081/150,633 (12.7; 12.7) | 1.22 (1.20–1.24) | 1.22 (1.20–1.25) |
| 5 (least deprived) | 9856/110,532 (8.9) | 12,122/107,279 (11.3; 11.2) | 1.27 (1.24–1.30) | 1.26 (1.22–1.29) |
| Residenceb,c | ||||
| Large urban area | 16,470/118,366 (13.9) | 20,278/115,689 (17.5; 17.5) | 1.26 (1.24–1.28) | 1.26 (1.23–1.28) |
| Urban area | 32,305/258,032 (12.5) | 40,939/253,421 (16.2; 16.1) | 1.29 (1.27–1.31) | 1.29 (1.27–1.31) |
| Accessible rural area | 18,953/179,545 (10.6) | 23,187/177,669 (13.1; 13.1) | 1.24 (1.21–1.26) | 1.24 (1.22–1.27) |
| Remote rural area | 2506/24,926 (10.1) | 2897/23,562 (12.3; 12.4) | 1.22 (1.16–1.29) | 1.24 (1.18–1.30) |
aDirect age-sex standardization to the 2012 population
bDeprivation and residence missing for 33,552 (5.5%) people registered in the index quarter of 2012 and 36,874 (6.1%) in 2019
cScottish Executive Urban–Rural Classification