Table 3.
Two-sample MR analysis results of MYL6/ACSL4 and sepsis.
| Exposure | Outcome | Method | NSNP | pval | OR | OR_95%LCI | OR_95%UCI | Statistical power |
|---|---|---|---|---|---|---|---|---|
| MYL6 | Sepsis | IVW | 10 | 0.419 | 0.962 | 0.876 | 1.057 | 0.25 |
| Sepsis (28-day death in critical care) | IVW | 10 | 0.005 | 2.169 | 1.259 | 3.736 | 1.00 | |
| Sepsis (critical care) | IVW | 10 | 0.102 | 1.252 | 0.956 | 1.640 | 1.00 | |
| Sepsis (28-day death) | IVW | 10 | 0.240 | 1.148 | 0.912 | 1.444 | 0.98 | |
| Sepsis (under 75) | IVW | 10 | 0.814 | 1.012 | 0.915 | 1.120 | 0.07 | |
| ACSL4 | Sepsis | IVW | 7 | 0.470 | 1.113 | 0.833 | 1.488 | 0.93 |
| Sepsis (28-day death in critical care) | IVW | 7 | 0.066 | 3.314 | 0.926 | 11.863 | 1.00 | |
| Sepsis (critical care) | IVW | 7 | 0.271 | 1.488 | 0.733 | 3.023 | 1.00 | |
| Sepsis (28-day death) | IVW | 7 | 0.551 | 1.171 | 0.697 | 1.965 | 1.00 | |
| Sepsis (under 75) | IVW | 7 | 0.851 | 0.970 | 0.703 | 1.338 | 0.16 |
NSNP, number of single-nucleotide polymorphisms number; OR, odds ratio; CI, confidence interval; UCI, upper limit of the confidence interval; LCI, lower limit of the confidence interval.