Table 4.

Tests for horizontal pleiotropy and heterogeneity in the MR analysis.

Exposure	Outcome	Horizontal pleiotropy test			Heterogeneity test
		egger_intercept	se	pval	Method	Q	Q_df	Q_pval
MYL6	Sepsis	−0.00461	0.0120	0.710	MR-Egger	8.103	8	0.423
					IVW	8.254	9	0.509
	Sepsis (28-day death in critical care)	−0.129	0.0685	0.0957	MR-Egger	3.168	8	0.923
					IVW	6.733	9	0.665
	Sepsis (critical care)	−0.0211	0.0341	0.553	MR-Egger	6.775	8	0.561
					IVW	7.159	9	0.621
	Sepsis (28-day death)	−0.00959	0.0290	0.750	MR-Egger	6.567	8	0.584
					IVW	6.676	9	0.671
	Sepsis (under 75)	0.00637	0.0133	0.646	MR-Egger	10.535	8	0.229
					IVW	10.834	9	0.287
ACSL4	Sepsis	0.0266	0.0264	0.361	MR-Egger	9.3610	5	0.096
					IVW	11.254	6	0.0808
	Sepsis (28-day death in critical care)	0.226	0.111	0.0974	MR-Egger	2.428	5	0.787
					IVW	6.574	6	0.362
	Sepsis (critical care)	0.0402	0.0685	0.582	MR-Egger	7.602	5	0.180
					IVW	8.127	6	0.229
	Sepsis (28-day death)	0.00156	0.0472	0.975	MR-Egger	2.087	5	0.837
					IVW	2.088	6	0.911
	Sepsis (under 75)	0.0230	0.0304	0.483	MR-Egger	12.951	5	0.0238
					IVW	14.437	6	0.0251

MR, Mendelian randomization; IVW, inverse variance weighted.