Figure 3.

Clinical association of metabolite/lipid signatures with disease progression. (A) We compared genes differentially expressed in HCC over cirrhosis from publicly available databases (full signatures) with the serum metabolite/lipid-related genes identified in our analysis to generate an overlap signature. (B) The number of differentially expressed genes (DEGs) of the four comparison groups from two public datasets (fold change >2, FDR<0.05) with the full signature on the left and the overlap signature on the right. (C) Full or overlap signatures were correlated with transcriptomics from cohorts of liver disease progression using a Pearson correlation coefficient (FDR<0.05 per dataset).