Table 3.
Recovery, matrix effect and stability of oseltamivir and oseltamivir acid.
| Characteristic | Quality control level (ng/ml), n = 6 | Average | RSD% | |||
|---|---|---|---|---|---|---|
| 0.50 | 1.00 | 100 | 800 | |||
| Oseltamivir | ||||||
| Recovery | 98.3% | 95.9% | 102% | 103% | 99.9% | 3.30% |
| Matrix effect | 83.3% | 85.2% | 83.3% | 82.8% | 83.7% | 1.00% |
| Benchtop stability | 107% | 100% | 113% | 108% | 107% | 5.37% |
| Autosampler stability | 113% | 100% | 107% | 102% | 106% | 5.80% |
| Freeze–thaw (3 cycles) stability | 115% | 103% | 111% | 105% | 109% | 5.31% |
| Oseltamivir acid | ||||||
| Recovery | 89.3% | 84.1% | 93.6% | 96.0% | 90.7% | 5.20% |
| Matrix effect | 96.1% | 96.9% | 95.1% | 94.5% | 95.6% | 1.10% |
| Benchtop stability | 117% | 108% | 111% | 108% | 111% | 4.10% |
| Autosampler stability | 114% | 104% | 108% | 104% | 107% | 4.68% |
| Freeze–thaw (3 cycles) stability | 117% | 106% | 111% | 109% | 111% | 4.57% |