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. 2024 Aug 29;14:1389468. doi: 10.3389/fonc.2024.1389468

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Copyright © 2024 Xie, An, Yang, Wang, Guo, Luo, Huang and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential mechanisms of drug resistance in patients with leukemia including mutations related to the Ras/MAPK signaling pathway occurring in patients after treatment with Gilteritinib. Increased MCL1 expression at VEN relapse was only partially explained by amplification of the MCL1 gene and increased MCL1 expression driven by NF-kB. AML cells that were resistant to chemotherapy showed premature accumulation during the early hematopoietic process. CD69 mediates drug resistance by regulating the mTOR-CCND1-CXCR4 axis.