Table 1.
Characterization of HPV disease spectrum in the GATA2 haplodeficient population.
| Total (n=52) | Female (n=27) | Male (n=25) | p-valuea | |
|---|---|---|---|---|
| Location | ||||
| Cutaneous/extragenital warts | 40 | 17 | 23 | 0.02 |
| Oral/tracheal HPV | 2 | 0 | 2 | 0.22 |
| Anogenital tract HPV overall | 32 | 20 | 12 | 0.09 |
| Anogenital tract HPV locationb | n/ac | |||
| Vulva (female)/scrotum, inguinal (male) | 19 | 14 | 5 | |
| Cervical, vaginal (female)/penile (male) | 22 | 14 | 8 | |
| Anal | 7 | 4 | 3 | |
| Anogenital Squamous Intraepithelial Neoplasia requiring treatment | 25 | 19 | 6 | 0.001 |
| i) Grade | 0.005 | |||
| LSIL | 4 | 3 | 1 | |
| HSIL | 21 | 16 | 5 | |
| (in Situ/Malignant) | (12) | (9) | (3) | |
| ii) Treatment | ||||
| Medical | 2d | 1d | 1 | |
| Surgical | 0.0009 | |||
| 1-2 | 11d | 7d | 4 | |
| > 3 | 13 | 12 | 1 | |
| iii) HSCT | 0.40 | |||
| Total | 20 | 12 | 8 | |
| HPV disease at time of transplant | 12 | 9 | 3 | |
| HPV vaccination | 11 | 11 | n/re | n/ac |
aFisher’s exact text comparing male and female cohorts; bMultiple locations common; cn/a is not appropriate for comparison; dboth medical and surgical approach in 1 patient; en/r is not recorded in medical records. HPV, human papillomavirus; LSIL, low-grade squamous intraepithelial lesion; HSIL, high-grade squamous intraepithelial lesion; HSCT, hematopoietic stem-cell transplantation.