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. 2024 Aug 29;15:1347770. doi: 10.3389/fimmu.2024.1347770

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Copyright © 2024 Ru, Cui, Wu, Tan, An, Wu, Ma, Hao, Xiao, Bai, Liu, Xia and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomic alterations differences between the HAS and LAS group from the TCGA-LUAD cohort. (A) Genomic alterations landscape between the HAS (left) and LAS (right) group. (B) Mutation frequency differences of the top 20 mutation genes in the HAS group compared to the LAS group. The asterisk to the right of the gene indicates that the mutations in the gene were significantly different in the two groups, as determined by Fisher’s exact test. (C) The TMB between HAS and LAS groups. The HAS group had a higher TMB (2.66 (IQR: 0.04, 11.985) compared to the LAS group (1.58 (IQR: 0.02, 6.9)) with P value = 0.000065 compared by the Wilcoxon test. The frequency of mutated genes in each tumor-related pathway (D, F) and DDR pathway (E, G) difference between two groups. The asterisks in (D, E) denote significant differences of mutated genes in different pathways identified by Fisher’s exact test which showed in (F, G).