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Activity of dual ligand designs 10–12 on the targets of interest
| ID | Structure | In vitro biol. activity |
|---|---|---|
| 10 |  |
AT1: inactive sEH: IC50 = 0.02 µM |
| 11 |  |
FFAR1: inactive sEH: IC50 = 0.061 µM |
| 12 |  |
FFAR1: EC50 = 8.5 µM AT1: inactive |
The dual AT1/sEH (10), FFAR1/sEH (11) and FFAR1/AT1 (12) ligand designs modulated only one of the targets of interest. Data are the mean; n ≥ 3.
