Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Sep 11;15:7963. doi: 10.1038/s41467-024-52214-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a Principal component analysis (PCA) on gene sets of normoglycemic (C) and hyperglycemic (DM) WT and F12^-/- mice kidneys. b Heatmap of the RNA-seq data showing the differentially expressed genes (DEGs) in WT-DM and F12^-/--DM mice. Each column represents data from an individual mouse. Color intensity represents row Z-score. c Gene set enrichment analysis (GSEA) plots of the hallmark gene sets representing key negatively enriched pathways when comparing F12^-/--DM to WT-DM kidneys. Significance is represented by the false discovery rate (FDR). d Bar graph representing the top enriched pathways based on the downregulated differentially expressed genes (DEGs) in F12^-/--DM compared to WT-DM kidneys using KEGG (Kyoto Encyclopedia of Genes and Genomes), WikiPathways, Reactome, PID (Pathway Interaction Database), and GO (Gene Ontology: Biological processes) databases. The pathways were ranked by the false discovery rate (FDR). Source data are provided as a “Source Data” file.