Table 4.

Two-sample MR analysis for the causal relationship between psoriasis and site-specific cancers

Outcome	Methods	OR (95% CI)	p value
Anal canal cancer	MR-Egger	1.05 (0.61, 1.78)	0.874
	Weighted median	1.01 (0.65, 1.57)	0.958
	Inverse variance weighted	1.00 (0.70, 1.44)	0.989
	Weighted mode	1.03 (0.67, 1.58)	0.902
Lung cancer	MR-Egger	1.13 (0.99, 1.29)	0.113
	Weighted median	1.12 (1.03, 1.23)	0.012
	Inverse variance weighted	1.12 (1.02, 1.22)	0.013
	Weighted mode	1.13 (1.03, 1.24)	0.034
Non-melanoma skin cancer	MR-Egger	1.00 (1.00, 1.00)	0.499
	Weighted median	1.00 (1.00,1.00)	0.820
	Inverse variance weighted	1.00 (1.00, 1.00)	0.500
	Weighted mode	1.00 (1.00, 1.00)	0.914
Breast cancer	MR-Egger	1.02 (1.01, 1.04)	0.024
	Weighted median	1.02 (1.01, 1.03)	0.008
	Inverse variance weighted	1.02 (1.01, 1.03)	0.002
	Weighted mode	1.02 (1.01, 1.03)	0.006
Kidney cancer	MR-Egger	1.15 (0.93, 1.42)	0.236
	Weighted median	1.12 (0.99, 1.26)	0.075
	Inverse variance weighted	1.06 (0.91, 1.23)	0.426
	Weighted mode	1.12 (0.99, 1.27)	0.110
Secondary malignant neoplasm of respiratory and digestive organs	MR-Egger	1.00 (1.00, 1.00)	0.572
	Weighted median	1.00 (1.00, 1.00)	0.669
	Inverse variance weighted	1.00 (1.00, 1.00)	0.391
	Weighted mode	1.00 (1.00, 1.00)	0.666
Secondary malignant neoplasm of other sites	MR-Egger	1.00 (1.00, 1.00)	0.044
	Weighted median	1.00 (1.00, 1.00)	0.033
	Inverse variance weighted	1.00 (1.00, 1.00)	0.071
	Weighted mode	1.00 (1.00, 1.00)	0.047
Follicular [nodular] non-Hodgkin’s lymphoma	MR-Egger	1.36 (1.03,1.79)	0.060
	Weighted median	1.21 (0.97, 1.51)	0.088
	Inverse variance weighted	1.09 (0.89, 1.33)	0.406
	Weighted mode	1.22 (0.96, 1.54)	0.129

All statistical tests are two-sided and unadjusted for multiple comparisons.

MR Mendelian randomization, OR odds ratio, CI confidence interval, MR-Egger Mendelian randomization-Egger.