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. 2024 Sep 5;13(9):bio060542. doi: 10.1242/bio.060542

Fig. 3.

Fig. 3.

Microdystrophin restores dystrophin expression and decreases LDH release in DMD-iSkMs. (A) Schematic of experimental design for AAV treatment studies. (B) DMD-iSkM+AAV cells had a significant increase in dystrophin expression as compared to DMD-iSkM+VEH (P-value=0.0055) and N-iSkM+VEH groups (P-value=0.0256). (C) IF detected dystrophin expression in N-iSkM+VEH and DMD-iSkM+AAV but not DMD-iSkMs+VEH. (D) LDH release was significantly increased in DMD-iSkM+VEH non-stressed cells as compared to N-iSkM+VEH (P-value<0.0001) while LDH release was restored similar to non-stressed N-iSkM+VEH levels in non-stressed DMD-iSkM AAV cells (P-value=0.0003). P-value, *≤0.05, **≤0.01, ***≤0.001, ****≤0.0001.