Fig. 2.
Assessment of RNFL thickness in the untreated and FP802-treated SOD1G93A ALS mouse model. A Representative images of 0.5 µm thick paraffin-embedded retinal sections stained with H&E from WT, SOD1G93A 20W (Veh) and SOD1G93A 20W (FP802) mice (scale bar = 200 µm). B RNFL thickness was measured with increasing distance from the center of the optic disk. Statistical test: two-way ANOVA with post-hoc Tukey’s multiple comparisons test. C The average thickness of the RNFL over the whole distance of 1800 µm from the center of the optic disk was calculated using measurements taken at 200 µm intervals. Statistical test: two-way ANOVA with post-hoc Tukey’s multiple comparisons test. n (B, C), WT = 6; SOD1G93A 20W (Veh) = 7; SOD1G93A 20W (FP802) = 4. Single eyes per mouse. ∗p < 0.05