Table 5.
The correlation between frozen section diagnosis and clinicopathologic features of the patients.
| Characteristics | Diagnosis with concordance (N=657) | Diagnosis with discrepancy (N=213) | P |
|---|---|---|---|
| Age, median (range) | 62 (29–75) | 62 (30–81) | 0.434 |
| Gender, n (%) | 0.662 | ||
| Male | 264 (40.2) | 82 (38.5) | |
| Female | 393 (59.8) | 131 (61.5) | |
| Smoking history, n (%) | 0.628 | ||
| Ever smoker | 180 (27.4) | 62 (29.1) | |
| Never smoker | 477 (72.6) | 151 (70.9) | |
| Median size (range), cm | 1.6 (0.5–4.8) | 1.65 (0.5–4.0) | |
| Range of resection, n (%) | 0.019 | ||
| LOB | 306 (46.6) | 76 (35.7) | |
| SEG | 219 (33.3) | 83 (39.0) | |
| WED | 132 (20.1) | 54 (25.4) | |
| pT staging, n (%) | 0.122 | ||
| pT1a | 87 (13.2) | 22 (10.3) | |
| pT1b | 345 (52.5) | 129 (60.6) | |
| pT1c | 138 (21.0) | 33 (15.5) | |
| pT2a | 82 (12.5) | 29 (13.6) | |
| pT2b | 5 (0.7) | 0 | |
| pN staging, n (%) | 0.727 | ||
| pN0 | 604 (91.9) | 197 (92.5) | |
| pN1 | 24 (3.7) | 9 (4.2) | |
| pN2 | 29 (4.4) | 7 (3.3) | |
| LVI+ | 91 (15.0) | 40 (19.1) | 0.081 |
| VPI+ | 90 (13.5) | 26 (12.5) | 0.578 |
| STAS+ | 178 (27.0) | 55 (26.2) | 0.716 |
| LVI+ (FS) | 79 (12.0) | 18 (8.5) | 0.150 |
| VPI+ (FS) | 92 (14.0) | 24 (11.2) | 0.307 |
| STAS+ (FS) | 122 (18.6) | 21 (9.9) | 0.438 |
| Predominant subtypes (FP) | ＜0.001 | ||
| L | 57 (8.7) | 27 (12.7) | |
| A | 472 (71.8) | 122 (57.3) | |
| P | 94 (14.3) | 39 (18.3) | |
| S | 31 (4.7) | 12 (5.6) | |
| M | 3 (0.5) | 13 (6.1) | |
| Predominant subtypes (FS) | ＜0.001 | ||
| L | 57 (8.7) | 41 (19.2) | |
| A | 472 (71.8) | 75 (35.2) | |
| P | 94 (14.3) | 41 (19.2) | |
| S | 31 (4.7) | 24 (11.3) | |
| M | 3 (0.5) | 2 (0.9) | |
| Presence of subtypes (FP) | |||
| L | 325 (49.5) | 111 (52.1) | 0.502 |
| A | 601 (91.5) | 197 (92.5) | 0.641 |
| P | 355 (54.0) | 140 (65.7) | 0.003 |
| S | 91 (13.9) | 35 (16.4) | 0.352 |
| M | 179 (27.2) | 60 (28.2) | 0.793 |
| CGP | 184 (28.0) | 72 (33.8) | ＜0.001 |
| Presence of subtypes (FS) | |||
| L | 386 (58.8) | 138 (64.8) | 0.118 |
| A | 560 (85.2) | 133 (62.4) | ＜0.001 |
| P | 271 (41.2) | 104 (48.8) | 0.052 |
| S | 103 (15.7) | 43 (20.2) | 0.126 |
| M | 132 (20.1) | 39 (18.3) | 0.635 |
| CGP | 232 (35.3) | 54 (25.4) | 0.011 |
A, acinar pattern; CGP, complex glandular pattern; FP, final pathology; FS, frozen section; L, lepidic pattern; LVI, lympho-vascular invasion; M, micropapillary pattern; P, papillary pattern; S, solid pattern; STAS, spread through air space; VPI, visceral pleural invasion.