FIG. 3.

Changes in viral burdens and hematologic parameters in macaques inoculated with SIVmac239 and Tyr-721 mutants. Animals designated by a dagger in the plasma RNA panels either died or were euthanized due to SIV-induced immunodeficiency. Plasma RNA levels were determined by the bDNA assay, which had levels of sensitivity of either 10⁴ or 1,500 copies/ml, depending on the time at which the assay was performed. Some samples were tested by QC RT-PCR, for which the sensitivity was 300 copies/ml. All points below the dotted lines were negative by both assays, with the exception of two values marked by an asterisk. These values were 350 and 800 copies/ml, respectively, for AGP at 4 weeks and N8G at 20 weeks after infection.