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. Author manuscript; available in PMC: 2024 Sep 15.
Published in final edited form as: J Neuroimmunol. 2023 Jul 5;382:578143. doi: 10.1016/j.jneuroim.2023.578143

Figure 2: Active SARS-CoV-2 and MOG-specific T cell responses with neuroaxonal damage.

Figure 2:

A. Activated T cells (CD38+HLA-DR+) were detectable in PBMC derived from Covid ON patients. B. Plasma neurofilament light chain level, but not GAFP level are higher in Covid ON patients compared to healthy control or non-covid neuromyelitis optica patient. C. Antigen specific CD4+ T cell activation (CD25+CD134+) in response to 24hr in vitro stimulation with solvent control DMSO, or SARS-CoV-2 CD4 epitope mega peptide pool (1ug/ml) (Grifoni et al., 2020) or human MOG overlapping peptide pool (1ug/ml). D. Antigen specific CD8+T cell activation (CD69+CD137+) in response to 24hr in vitro stimulation with solvent control DMSO, or SARS-CoV-2 CD8 epitope mega peptide pool (Grifoni et al., 2020) (1ug/ml).