Table 2.
Clinical inflammation- and thrombosis-associated biomarkers sorted according to COVID-19 patients` genotypes of the 4G/5G and + >43 G PAI-1 gene polymorphisms.
| Thrombosis-associated marker | 4G4G (n=11) | 4G5G (n=10) | p-values | 4G4G (n=11) | 5G5G (n=10) | p-values | GG (n=39) | GA (n=7) | p-values |
|---|---|---|---|---|---|---|---|---|---|
| D-Dimer (0-1µg/dL) | 1.75 [1.3-2.08] | 1.5 [1.2-1.8] | 0.4976 | 1.75 [1.3-2.08] | 1.9 [1.35-2.6] | 0.8199 | 1.65 [1.23-2.0] | 1.9 [1.25-8.9] | 0.3542 |
| Fibrinogen (150 - 400mg/dL) | 418.0 [363.5-504.0] | 402.0 [358.5-510.5] | 0.9070 | 418.0 [363.5-504.0] | 381.0 [349.25-591.5] | 0.8461 | 453.5 [376.0-577.0] | 358.0 [311.5-388.0] | 0.2409 |
| Platelets (153-346x103/µL) | 207.0 [166.0-228.75] | 200.0 [170.0-220.0] | 0.6219 | 207.0 [166.0-228.75] | 203.5 [173.75-223.25] | 1 | 196.0 [166.0-226.0] | 204.0 [187.5-220.5] | 0.6954 |
| PT INR | 0.99 [0.98-1.0] | 0.99 [0.96-1.04] | 0.7594 | 0.99 [0.98-1.0] | 1.0 [0.95-1.07] | 0.8083 | 0.99 [0.96-1.04] | 1.0 [0.95-1.1] | 1 |
| Troponin T(0-0.1ng/dL) | 3.5 [0.76-4.0] | 5.0 [4.5-10.0] | 0.0278 | 3.5 [0.76-4.0] | 8.0 [3.0-12.25] | 0.0893 | 5.0 [3.0-8.75] | 5.0 [4.0-11.0] | 0.5043 |
| Inflammation-associated marker | |||||||||
| WBC (3.9-9.7 x103/µL) | 4.85 [3.88-5.58] | 4.5 [3.6-5.9] | 0.9417 | 4.85 [3.88-5.58] | 4.65 [4.32-6.1] | 0.7623 | 4.85 [3.8-5.98] | 4.2 [3.7-4.4] | 0.3393 |
| Neutrophil (25-60 x102/µL) | 3.31 [2.69-828.89] | 3.0 [2.24-4.51] | 0.3518 | 3.31 [2.69-828.89] | 4.46 [1.9-8.76] | 0.7337 | 3.34 [2.43-6.19] | 2.59 [1.87-4.68] | 0.3161 |
| Lymphocytes (x10²/µL) | 28.95 [20.98-30.4] | 30.5 [20.4-37.0] | 0.4764 | 28.95 [20.98-30.4] | 20.8 [12.78-34.75] | 0.6775 | 28.55 [19.27-35.12] | 32.2 [16.85-39.45] | 0.6954 |
| CRP (0-0.29mg/dL) | 0.66 [0.24-3.19] | 0.65 [0.15-4.31] | 0.8408 | 0.66 [0.24-3.19] | 0.34 [0.1-5.9] | 0.7622 | 0.66 [0.15-4.2] | 0.18 [0.14-3.42] | 0.6497 |
| IL6 (0-4pg/mL) | 3.9 [2.8-7.1] | 4.9 [2.1-18.15] | 0.6149 | 3.9 [2.8-7.1] | 4.1 [1.6-5.6] | 0.7572 | 4.6 [1.8-12.4] | 4.1 [2.35-6.0] | 0.8083 |
| Procalcitonin(0-0.04ng/dL) | 0.06 [0.04-0.08] | 0.05 [0.03-0.07] | 0.7544 | 0.06 [0.04-0.08] | 0.04 [0.03-0.06] | 0.4019 | 0.05 [0.03-0.08] | 0.04 [0.03-0.06] | 0.4035 |
Data are means [range] of absolute values per patient obtained at diagnosis. P-values were obtained by comparing the values of a biomarker, considering the genotype, and calculated by X2 or Fischer’s exact test. PT INR, expressed as International Normalized Ratio; prothrombin; WBC, white blood cell counts; IL6, interleukin-6; CRP, C-reactive protein. The data presented here were part of a more extensive study and were analyzed according to patient genotypes [see (14)].