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. 2023 Nov 16;42(9):1404–1416. doi: 10.1038/s41587-023-01977-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a–l, Replication of the NE differentiation in W24B (a-f) and W24M (g-l) hiPSCs. a,b,g,h, Immunostaining for NE progenitor markers ASCL1, PHOX2B and PHOX2A at day 11. c,d,i,j, Immunostaining for NE markers PHOX2B, TH and DBH at day 18 (c, i) and day 30 (d,j). e,k, Immunostaining for PNMT in culture. HO, Hoechst. scale bars (a, b, g, h), 50 μm; scale bars (c-e,i-k): 20 μm. f,l, Quantification of PHOX2B and PHOX2B/TH positive cells in culture. Data are shown as mean ± s.d. n = 5 biologically independent samples for each condition.

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