Extended Data Fig. 1. LIANA+ provides scalable implementations of cell–cell communication methods.
Efficiency benchmark of A) dissociated methods and B) spatially weighted local metrics implemented in LIANA + . Time in log2 of seconds and peak total RAM (memory) usage are shown over a number of simulated datasets with observations (cells) ranging from 1000 to 100,000 (1k to 100k). Masked Spearman Correlation was excluded for the 100k dataset. C) Multi-view learning of cell-type spatial patterns across a range of views. RAM Usage is not shown as it was relatively constant at ~2,900MB ( ± 100MB) across views. D) Multi-view factor analysis used to identify intercellular programmes across a range of cell-type pairs (views). The median time in minutes and RAM usage are shown across five independent runs for each method. Source numerical data are available in source data.