FIG. 1.

(A) Alignment of deduced Vpx protein sequences from divergent HIV-2 and SIV isolates. Sequences are compared to the SIVsm(PBj1.9) Vpx protein sequence. Dots indicate amino acid sequence identity. Dashes represent gaps inserted to improve the alignment. The HIV-2/SIV Vpx sequences shown were obtained from the Los Alamos HIV sequence database (http://hiv-web.lanl.gov/), except for the deduced Vpx protein sequence of SIVrcm(GB1), which is unpublished. (B) Alignment of Vpx [SIVsm(PBj1.9)] and Vpr [HIV-1(89.6)] protein sequences. Groups of amino acid residues chosen for mutagenesis are highlighted in color.