Table 2.
Comparison of the plasma aldosterone concentration, direct renin concentration, and aldosterone/renin ratio values in all patients receiving different false negative drugs
| Classification | Variable | Pre-washout | Post-washout | p value | False-positive (%) | False-negative (%) |
|---|---|---|---|---|---|---|
| ACEIs/ARBs (n = 84) | ||||||
| PAC [M (P25, P75), ng/dL] | 11.20 (7.90, 18.00) | 14.10 (9.67, 19.80) | 0.038 | 0 | 18.18 | |
| DRC [M (P25, P75), mU/L] | 24.59 (6.07, 65.42) | 11.70 (3.25, 23.55) | < 0.001 | |||
| ARR [M (P25, P75), (ng/dL)/(mU/L)] | 0.44 (0.17, 2.65) | 1.05 (0.45, 2.89) | 0.014 | |||
| CCBs (n = 210) | ||||||
| PAC [M (P25, P75), ng/dL] | 11.85 (6.98, 18.68) | 16.50 (10.98, 22.13) | 0.061 | 14.39 | 33.33 | |
| DRC [M (P25, P75), mU/L] | 9.00 (3.20, 22.30) | 7.95 (2.70, 15.97) | 0.303 | |||
| ARR [M (P25, P75), (ng/dL)/(mU/L)] | 1.15 (0.42, 6.22) | 2.20 (1.04, 6.04) | 0.248 | |||
ACEIs angiotensin-converting enzyme inhibitors, ARBs angiotensin receptor blockers, CCBs calcium channel blockers, PAC plasma aldosterone concentration, DRC direct renin concentration, ARR aldosterone/renin ratio, M median, P25 the first quartile, P75 the third quartile
False-Positive: The number of patients with a positive pre-wash ARR but negative post-wash ARR was divided by the total number of patients with negative post-wash ARR, multiplied by 100%
False-Negative: The number of patients with a negative pre-wash ARR but positive post-wash ARR was divided by the total number of patients a with positive post-wash ARR, multiplied by 100%
A p value < 0.05 was considered statistically significant