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. 2024 Aug 15;16(9):2146–2169. doi: 10.1038/s44321-024-00117-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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Figure EV3 — (A) Representative images of immunofluorescence staining of infiltrating neutrophils (Ly6G, green) in brain lesions. Scale bar = 20 µm. (B) The statistical analysis of infiltrating neutrophils (Ly6G rate) from the following experimental groups: tPA (5 h) (n = 12), tPA (5 h) + HRG (n = 11), and tPA (5 h) + HRG siRNA groups (n = 8). The data are also partially used in Fig. 6H. (C–E) Neurological deficits were measured by assessing the Bederson score (C), corner test (D) and adhesive removal test (E) in mice treated with tPA (5 h), tPA (5 h) + HRG, tPA (5 h) + HRG siRNA, tPA (5 h) + HRG siRNA + anti-Ly6G, and tPA (5 h) + HRG siRNA + Dnase I (n = 8 per group). (F) Representative images of the dorsal surface and a coronal section showing cerebral hemorrhage 24 h after stroke. (G) Quantification of cerebral hemorrhage by spectrophotometric hemoglobin assay (n = 8). Data information: Data are presented as mean ± SEM. Two-tailed Kruskal–Wallis H test is used in (B–E, G). Source data are available online for this figure.