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Overview of the study design and participant flow. Our study participants were drawn from UK Biobank, while the calculation of polygenic scores leveraged previous genome-wide association studies of blood lipids. AFR, African; CSA, Central/South Asian; EAS, East Asian; EUR, European; GWAS, genome-wide association study; Pan-UKBB, Pan-ancestry genetic analysis of the UK Biobank; PGS, polygenic scores; UKB, UK Biobank.
