TABLE 2.
Association of lipid polygenic scores with the corresponding observed lipid concentrations stratified by the fish oil intake status in UKB participants of European ancestry1
| Fish oil intake |
No fish oil intake |
Interaction2 |
|||||
|---|---|---|---|---|---|---|---|
| Lipids | n | (95% CI) | n | (95% CI) | n | (95% CI) | P value |
| Total cholesterol | |||||||
| Model 13 | 128,634 | 0.244 (0.239, 0.249) | 276,134 | 0.265 (0.261, 0.268) | 404,768 | −0.022 (−0.028, −0.015) | 9.98×10-12 |
| Model 24 | 103,738 | 0.304 (0.299, 0.309) | 222,391 | 0.313 (0.310, 0.317) | 326,129 | −0.011 (−0.017, −0.005) | 3.53×10-4 |
| LDL cholesterol | |||||||
| Model 1 | 128,393 | 0.262 (0.257, 0.267) | 275,625 | 0.280 (0.277, 0.284) | 404,018 | −0.019 (−0.025, −0.012) | 6.27×10-9 |
| Model 2 | 103,538 | 0.323 (0.318, 0.328) | 221,994 | 0.332 (0.328, 0.335) | 325,532 | −0.010 (−0.016, −0.004) | 0.001 |
| HDL cholesterol | |||||||
| Model 1 | 117,709 | 0.235 (0.230, 0.240) | 252,786 | 0.230 (0.227, 0.234) | 370,495 | 0.005 (−0.001, 0.011) | 0.139 |
| Model 2 | 94,880 | 0.234 (0.229, 0.240) | 203,514 | 0.227 (0.224, 0.231) | 298,394 | 0.007 (0.001, 0.013) | 0.025 |
| Triglycerides | |||||||
| Model 1 | 128,544 | 0.252 (0.247, 0.257) | 275,897 | 0.265 (0.262, 0.269) | 404,441 | −0.013 (−0.020, −0.007) | 2.45×10-5 |
| Model 2 | 103,674 | 0.254 (0.248, 0.259) | 222,215 | 0.267 (0.263, 0.270) | 325,889 | −0.013 (−0.020, −0.007) | 5.42×10-5 |
The lipid polygenic scores were calculated by utilizing the P + T algorithm and the Graham et al. [19] GWAS with UKB excluded. refers to the change in the observed lipid concentration (in the unit of phenotypic SD) per SD increment in the PGS of the corresponding lipid. PGS, polygenic score; UKB, UK Biobank.
The interaction P values were obtained from the interaction term between lipid PGS and fish oil supplementation in corresponding models that further adjusted for lipid PGS and fish oil supplementation.
Model 1 adjusted for sex, age, age2, assessment centers, genotyping array, and the top 20 genetic principal components.
Model 2 additionally adjusted for BMI, Townsend deprivation index, smoking status, alcohol status, physical activity, and statin use.