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. 2024 Sep 12;15:7895. doi: 10.1038/s41467-024-51713-y

Fig. 2. Distribution of hotspot mutations by gene and TIER classification.

Fig. 2

a Distribution of mutated sites classified in each TIER. b Proportion of mutations in each gene by the total number of mutations in each TIER, by status. c Proportion of mutations in each gene by the total number of mutations in each TIER, by HPV type. Mutations from multiple HPV16/18/45 type co-infections were excluded. Footnote: CIN3 Cervical intraepithelial neoplasia grade 3, AIS adenocarcinoma in situ. P-values were estimated with two-sided Fisher’s Exact tests for count data with simulated p-values (based on 2000 replicates). Source data are provided as a Source Data file.