Table 1.

Distribution of mutated sites by gene and by TIER classification

	TIER1		TIER2		TIER3		PASSENGER
Gene	N	%	N	%	N	%	N	%
PIK3CA	8	29.6%	15	9.1%	117	9.5%	126	7.1%
FBXW7	6	22.2%	8	4.8%	117	9.5%	100	5.7%
KRAS	5	18.5%	7	4.2%	31	2.5%	35	2.0%
PTEN	2	7.4%	23	13.9%	63	5.1%	69	3.9%
ERBB3	2	7.4%	1	0.6%	82	6.6%	141	8.0%
TP53	1	3.7%	69	41.8%	123	10.0%	108	6.1%
ERBB2	1	3.7%	5	3.0%	81	6.6%	121	6.9%
EP300	1	3.7%	3	1.8%	199	16.1%	211	12.0%
MAPK1	1	3.7%	0	0.0%	13	1.1%	20	1.1%
ARID1A	0	0.0%	11	6.7%	112	9.1%	344	19.5%
STK11	0	0.0%	11	6.7%	35	2.8%	47	2.7%
NFE2L2	0	0.0%	5	3.0%	21	1.7%	59	3.3%
PIK3R1	0	0.0%	4	2.4%	64	5.2%	55	3.1%
HRAS	0	0.0%	3	1.8%	24	1.9%	35	2.0%
TGFBR2	0	0.0%	0	0.0%	76	6.1%	49	2.8%
CASP8	0	0.0%	0	0.0%	51	4.1%	61	3.5%
ELF1	0	0.0%	0	0.0%	16	1.3%	35	2.0%
HLA-B	0	0.0%	0	0.0%	10	0.8%	11	0.6%
HLA-A	0	0.0%	0	0.0%	1	0.1%	5	0.3%
MED1	0	0.0%	0	0.0%	0	0.0%	132	7.5%
Total	27	100.0%	165	100.0%	1236	100.0%	1764	100.0%