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Immunolocalization of LANA1 (A) compared with LANA2 (B) in a lymph node with CD as well as KS. While the KS spindle cells (area within guide lines) and some of the mantle zone lymphocytes show strong nuclear positivity to LANA1, the adjacent section immunostained with LANA2 only shows this protein expressed in the lymphocyte subpopulation of KSHV-infected cells in the mantle. The CD serves as an internal positive control for the negative LANA2 immunostaining of KS spindle cells.
