Figure 1.

Design of pediatric cancer gene panel. A, This study includes panel content, investigation of ultrasensitive detection, capture performance, diagnostic yield, and clinical applications. B, A Sankey diagram (82) showing spectrum of childhood cancers (Heme, hematologic malignancies; ST, solid tumors; Brain, brain tumors), cancer subtypes, genes, variant types, and genomic features targeted by SJPedPanel. Stacked bar plot at the right end shows space distribution of different genomic features covered by SJPedPanel.