Table 1.
Overview of the DNA panels selected for comparison.
| Panel name | Focus area | No. of genes | Genes screened for | SNP | % pediatric cancer driver genes covered out of reported 183 genesa | Publication | ||
|---|---|---|---|---|---|---|---|---|
| Coding exons | Selected introns | Promoter regions | ||||||
| SJPedPanel | Pediatric cancers | 357 | 357 | 94 | 10 | 7,590 | 87% | This study |
| FoundationOne Heme | Adult blood cancers | 418 | 408 | 31 | 57% | He and colleagues (20) | ||
| CHOP CHMP/CSTP | Pediatric cancers | 273b | 273 | 1 | 1,042 | 55% | Surrey and colleagues (23) | |
| MSK-IMPACT | Adult solid tumors | 468c | 468 | 13 | 1 | 862 | 52% | Cheng and colleagues (6) |
| OncoKids | Pediatric cancers | 181 | 137 | 44 | 1 | 49% | Hiemenz and colleagues (5) | |
| FoundationOne CDx | Adult solid tumors | 324 | 309 | 34 | 1 | 44% | Whitepaper by Companyd (21) | |
| Oncomine Comprehensive Assay v3 | Adult cancers | 161 | 146 | 15 | 1 | 29% | Hovelson and colleagues (25) | |
a
183 pediatric cancer genes are reported in two pediatric pan-cancer studies by Ma and colleagues (3) and Grobner and colleagues (2).
b
Considered unique genes from CHOP CHMP and CSTP panels reported in Surrey and colleagues (23).
c
The MSK-IMPACT panel is reported to include 468 genes, as it considers two different transcript isoforms for the CDKN2A gene. However, when counting only unique gene names, the panel consists of 467 genes.
d
Sources of content for all the panels are available in Supplementary Table S7A.