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. 2024 Sep 12;7(12):e202302041. doi: 10.26508/lsa.202302041

Figure 4. Higher CALCRL gene expression is associated with a higher Gleason score of prostate cancer.

Figure 4.

(A) Clinical information and calcitonin gene–related peptide receptor gene expression profiles (CALCRL, RAMP1, RAMP2, and RAMP3) of prostate cancer cohort (390 prostate cancer patients) obtained from The Cancer Genome Atlas database. (B, C, D, E) Correlation analyses between the Gleason score and the gene expression of (B) CALCRL, (C) RAMP1, (D) RAMP2, and (E) RAMP3. P ≤ 0.05 is considered as statistically significant (Spearman’s rank correlation coefficient). (F) Association analyses between the Gleason score, and CALCRL gene expression, RAMP1 gene expression, age at diagnosis, and PSA levels. P ≤ 0.05 is considered as statistically significant (multinomial logistic regression models). (G) Kaplan–Meier curves for the association of CALCRL with recurrence-free survival. P ≤ 0.05 is considered as statistically significant (log-rank test).