Figure S5. Anti-calcitonin gene–related peptide Ab treatment does not reduce tumor growth in bone in immunodeficient mice.

Luciferase-expressing human lung cancer cell line A549 was implanted directly into femurs of SCID mice (n = 11/group). These mice were treated intraperitoneally with either isotype control antibody (Ab) or anti-CGRP monoclonal Ab (30 mg/kg). Bone metastatic growth was measured by bioluminescence imaging. Data are the mean ± SEM. P ≤ 0.05 is considered as statistically significant (mixed-effects model).