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. Author manuscript; available in PMC: 2024 Sep 13.
Published in final edited form as: Regul Toxicol Pharmacol. 2023 May 18;141:105410. doi: 10.1016/j.yrtph.2023.105410

Fig. 3.

Fig. 3.

N-nitroso propranolol induced DNA strand breaks in 2D and 3D human HepaRG cultures. Both 2D (A) and 3D (B) HepaRG cells were exposed to N-nitroso propranolol for 24 h. The relative cell viability (% of control, a measure of cytotoxicity) was measured by the ATP assay (right y-axis and red line). DNA damage (% tail DNA) was detected using the CometChip assay (left y-axis and black bars). The data are expressed as the mean ± SD (n ≥ 3). * indicates comparison with the negative control was significant at P < 0.05.