Figure 3.

Colocalization and mediation between cis-CpGs and cis-eGenes

(A) The proportion of cis-CpGs and cis-eGenes associated with at least one colocalizing QTL and the proportion of cis-meQTLs and cis-eQTLs that colocalize.

(B) The proportion of cis-CpGs and cis-eGenes with at least one colocalized QTL that also show evidence of mediation via SEM or SME.

(C) Proportion of effect mediated versus significance of the mediation effect (-log10(Sobel test p value). Only results with a positive proportion of the effect mediated are shown. Mediation analyses under the SME model tended to have a larger proportion of effect mediated than results from the SEM model. Purple and yellow dashed lines indicate the FDR 5% threshold for SEM and SME Sobel mediation tests, respectively.

(D) SME and SEM pathways.