Table 2. Aggregation Temperature (Tagg) for HUP-46, KYP-2091, and KYP-2112 in PREP and PREP Mutantsa.
| Tagg (°C) | hPREP | Asn483Ala | Leu499Cys | Tyr471Ala |
|---|---|---|---|---|
| DMSO | 48.9 ± 0.4 | 47.8 ± 0.4 | 47.7 ± 0.4 | 47.2 ± 0.5 |
| HUP-46 | 53.2 ± 1.5 | 48.5 ± 0.4 | 48.3 ± 0.4 | n.d. |
| KYP-2091 | 52.5 ± 1.0 | 49.3 ± 1.2 | 50.6 ± 4.6 | 47.8 ± 0.8 |
| KYP-2112 | 52.2 ± 1.3 | 50.6 ± 1.0 | 54.2 ± 0.9 | 50.5 ± 0.5 |
n.d.: not detected.