Table 2.

Summary of clinical course, histopathologic findings, and typical treatment and prognosis for each entity of CTCL described in our cases. Information obtained from Atlas of Cutaneous Lymphomas: Classification and Differential Diagnosis [3], Kempf et al. [4], Guitart et al. [5], and Dermatopathology, Cutaneous Lymphomas [35].

CD8+ Subtype	Clinical Features	IHC	Treatment
CD8+ MF	Hypopigmented or hyperpigmented pruritic, scaly plaques	CD3+, CD7− CD8+, CD30+/− CD56−, CCR4+ Cytotoxic granules- (TIA-GZM-)	Early: topical steroids and/or retinoids, phototherapy, RT Advanced: bexarotene, IFNα, ECP, chemotherapy, stem cell transplant
LyP type D	Small nodules and papules, enlarge over 3–12 wks (w/wo ulceration), then change color to red-brown as they regress on their own	CD3+, CD4− CD8+, CD25+ CD30+, CD45RO+ CD56+/− Cytotoxic granules+ (TIA+GZM+)	Topical steroids, phototherapy, low-dose MTX Recurrence is common
SPTCL	Deep subcutaneous tumors or plaques, mimics panniculitis	CD4−, CD5−, CD8+, CD30+/−, and CD56− Cytotoxic granules+ (TIA+GZM+)	Prednisone, MTX, bexarotene, romidepsin, chemotherapy
PCGDTL	Erythematous to violaceous patches, plaques, or nodules with ulceration and necrosis on trunk and extremities	CD2+, CD3+, CD4−, CD5−, CD8 +/−, CD30+/−, CD56+, Cytotoxic granules+ (TIA+GZM+)	Chemotherapy, though almost always fatal
CD8+ AECTCL	Plaques > tumors with ulceration and necrosis; mucosal surfaces, palms, and sole involvement	CD3+, CD4− CD5−, CD8+ CD30− Cytotoxic granules+ (TIA+GZM+)	Chemotherapy, localized RT IFNα may worsen disease
Acral CD8+ TCLPD	Solitary nodular lesion or plaque on ears, nose, or retroarticular area	CD3+, CD4− CD8+, CD30− CD56− Cytotoxic granules+/− (TIA+, GZM−)	RT or surgical excision

RT: radiation therapy; IFNα: interferon alpha; MTX: methotrexate.