Table 3.

Some ongoing studies concerning IBD patients and the risk associated with CRC. IBD, inflammatory bowel disease; CRC, colorectal cancer; HD, high definition; WLE, white-light endoscopy; CE, chromoendoscopy; UC, ulcerative colitis; CD, Crohn’s disease; PSC, primary sclerosing cholangitis; IBD-U, inflammatory bowel disease unclassified; LCI, linked color imaging.

Study Title	Aim of the Study	Patients	NCT Number
IBD neoplasia surveillance pilot RCT (IBD Dysplasia)	Random and targeted biopsies vs. targeted biopsies alone for CRC screening in adult persons with colonic IBD	600 with long-standing CD or UC or any disease duration in case of PSC	NCT04067778
Back-to-back endoscopy versus single-pass endoscopy and CE in IBD surveillance (HELIOS)	Back-to-back HD-WLE vs. single-pass HD-WLE vs. CE	563 with long-standing CD or UC or any disease duration in case of PSC	NCT04291976
HD colonoscopy vs. dye-spraying chromo-colonoscopy in screening patients with long-standing IBD	HD colonoscopy vs. dye-spraying chromo-colonoscopy	500 (estimated) with long-standing CD, UC, or IBD-U or any disease duration in case of PSC	NCT04191655
LCI vs. WLE for colorectal dysplasia in UC	LCI vs. conventional colonoscopy using WL for detection of colorectal dysplasia in UC	60 (estimated) with UC	NCT02772406
Dysplasia in inflammatory chronic idiopathic colitis long-standing	Assess the incidence of dysplasia and CRC in patients with chronic idiopathic inflammatory colitis treated with biologics, mesalamine, and immunosuppressive drug combinations	300 (estimated) with long-standing CD or UC	NCT03096717
Testing atorvastatin to lower colon cancer risk in long-standing UC	To determine the effect of atorvastatin treatment on reducing the fraction of colonic epithelial cells expressing mutant p53 protein	70 (estimated) with long-standing UC	NCT04767984