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Relative gene expression of WNT pathway components in fibroblasts and osteoblast-like cells of PLS3-variant patients. Fibroblasts and osteoblast-like cells from six PLS3-variant patients and five controls. (A) The heat map shows the relative gene expression measured by qPCR. GAPDH was used to normalize gene expression. Relative gene expression of (B) WNT1, (C) WNT2, and (D) SFRP1, FZD3, NFATC1, NFATC2, and CTNND2 (* p < 0.05, **** p < 0.0001).
