Figure 3.

Expression levels of PI3K/Akt/NF-κB pathway proteins and inflammatory factors in E. granulosus-sensitized lung tissues. (A–D) In Western blot results, compared with inoculation control group (group A), the protein expression level of PI3K/Akt/NF-κB pathway is significantly increased in the PI3K blocker group (group B) and the AKT blocker group (group C) (P < 0.05). The protein expression level of PI3K/Akt/NF-κB pathway in hydatid sac fluid sensitized group is significantly increased (group D) (P < 0.05). Compared with groups B and C, the expression levels of the above pathway proteins in group D are significantly increased (P < 0.05). (E, F) The expression of inflammatory cytokines IL-6 and TNF-α protein is consistent with the expression trend of the PI3K/Akt/Akt/NF-κB pathway protein. Statistical significance compared to group A is indicated as follows: *: P < 0.05; **: P < 0.01; ***: P < 0.001; ****: P < 0.0001.