Figure 4.

Virtual clones with identical tumor-immune characteristics but different initial tumor compositions show varied long-term responses to checkpoint blockade therapy. (A) Volumes of ODE-simulated virtual tumors. (B–D) Volumes of ABM-simulated virtual tumors. (E) Ratio of low-antigen (LA) tumor cells to total tumor cells in ODE-simulated virtual tumors. (F–H) Ratio of LA tumor cell to total tumor cell in ABM-simulated virtual tumors. Colors show different compositions of the initial tumor. Blue: 80% LA tumor cells, 20% HA tumor cell. Green: 50% LA, 50% LA. Orange: 20% LA, 80% HA. ODE parameters for virtual clones in (A,E): ${\alpha }_{nt}=0.32,\mu =2\times {10}^4$. ABM parameters for virtual clones in (B–D) and (F–H): ${\alpha }_{nt}=0.32,\mu =15$. Other parameters are set at baseline.