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Roles of intratumoral bacteria in tumor metastasis. Bacteria inside the primary tumor could be transported to the metastasized tumor along with tumor cells. During metastasis, intratumoral bacteria assist the process in several different aspects. These include promotion of EMT, production of MMP, resistance to fluid sheer stress (FSS), and immune suppression. Arrows in different colors (yellow, red, and pink) indicate FSS at different locations.
