Figure 1:

The Free Water partial volume effects manifest at the boundary between brain tissue and ventricles filled with cerebrospinal fluid (CSF). The image to the right presents a pristine slice where the distinction between the brain tissue and CSF is sharp and clear. In contrast, the central image reveals partial volume effects in voxels encompassing both CSF and tissue, as indicated by the yellow arrows. The primary objective of the proposed algorithm is to extract parameter estimates that are exclusive to the tissue within these voxels.