Table 3.

Univariate survival analysis in 32 osteosarcomas.

Characteristics	No.	OS		RFS
		HR (95% CI)	p	HR (95% CI)	p
Age, years, ≥30 (vs. <30)	8/32	3.071 (1.105–8.532)	0.031	3.139 (1.128–8.739)	0.029
Sex, male (vs. female)	20/32	0.874 (0.298–2.567)	0.807	0.768 (0.263–2.246)	0.630
TNM stage, ≥IIB (vs. IIA)	17/32	2.865 (0.983–8.349)	0.054	2.912 (0.997–8.507)	0.051
T category, T2 and T3 (vs. T1)	16/32	3.009 (1.035–8.750)	0.043	3.142 (1.079–9.150)	0.036
N category, N1 (vs. N0)	2/32	3.830 (0.441–33.245)	0.223	2.047 (0.255–16.465)	0.501
M category, M1 (vs. M0)	5/32	3.297 (0.904–12.025)	0.071	2.553 (0.703–9.277)	0.155
PAK4, positive (vs. negative)	18/32	7.646 (1.726–33.875)	0.007	7.981 (1.801–35.369)	0.006
PD–L1, positive (vs. negative)	13/32	5.195 (1.768–15.260)	0.003	5.157 (1.768–15.039)	0.003

OS, overall survival; RFS, relapse-free survival; HR, hazard ratio; 95% CI, 95% confidence interval; TNM, tumor node metastasis.