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. 2024 Sep 4;13(17):1484. doi: 10.3390/cells13171484

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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HIF1α-mediated expression of HOTAIR in the HeLa cell line (A) HOTAIR promoter is enriched with Wnt response elements (WRE) and hypoxia response elements (HRE). (B,C) Stabilization of HIF1α by DMOG and assessment of its transcriptional activity in the HeLa cell line. (D) Over-activation of the transcriptional activity of Wnt/β- catenin by LiCl in HeLa cell line. (E,F) HOTAIR expression upon over-activation of HIF1α and Wnt/β-catenin pathway transcriptional activity by LiCl and DMOG in HeLa cell line. (G) HIF-1α is located in HOTAIR promoter by ChIP assay. p < 0.05 (*). p < 0.01 (**). p < 0.001 (***).