Table 1.

Clinical cohort overview.

PATIENT	Age	Sample Time Points	Study Length (Days)	Neo-adyuvance	FIGO	PCI	R Surgery	Relapse	Origin	Exitus	Mutation(s) Identified by NGS	Mutation-Specific ctDNA Detected by dPCR (Líquid Biopsy)	Verified in Tumor by dPCR (Tumor Tissue)	Further NGS-Identified Pathogenic Mutations	Further NGS-Identified Mutations Classified as VUS (Variant of Uncertain Significance)
1	61	5	538	YES	IIIC	30	R1	YES	Bulgarian	YES				TP53 C135Sfs*35
2	42	5	391	YES	IVA	18	R1	YES	Spanish	YES				BRCA2 G2793V
3	61	6	882	NO	IIIC2	2	R0	NO	Spanish	NO
4	72	5	401	YES	IVB	11		YES		YES					TP53 P27L
5	70	4	400	YES	IIIA2	7	R0	YES	Spanish	NO	TP53 R175H	+	+	BRCA1 T688*
6	80	4	384	YES	IIB	23	R0	YES	Spanish	NO
7	70	3	301	NO	IVB	9	R1	NO	Spanish	NO	TP53 R175H BRCA1 E1210R	+	+
8	60	6	997	NO	IVB	18	R0	YES	Spanish	NO	TP53 p.?	+	+
9	63	4	357	YES	IIIC	12		YES		YES				TP53 A86Hfs*37 BRCA2 K3326*
10	53	9	933	YES	IIIA2	16	R0	NO	Moroccan	NO	TP53 G245D	o	+	BRCA1 G1770V
11	51	7	812	YES	IIIC	21	R0	YES	Romanian	NO	BRCA1 E272* TP53 R248Q	+ +	+ +
12	75	7	835	YES	NA	35	R0	YES	Spanish	NO
13	75	4	356	NO	IIIC	13	R0	YES	Spanish	NO				TP53 c.911_919+7delCTAAGCGAGGTAAGCA
14	51	4	532	YES	IIIA	22	R0	NO	Chinese	NO	TP53 Y220C	+	+	BRCA2 S611Yfs*5	BRCA1 K654R
15	53	4	365	NO	IC	10	R0	NO	Spanish	NO				BRCA1 Y655* C994*
16	74	7	314	NO	IIIA	17	R0	NO	Spanish	NO	TP53 R249S	+	+	TP53 R254S
17	64	5	288	NO	IIIB	7	R0	NO	Spanish	NO
18	59	5	300	NO	IIIc	12	R0	NO	Spanish	NO				TP53 C275F
19	63	5	280	YES	IVa	19	R1	YES	Spanish	NO				BRCA2c.8332-1G>A = p.?	BRCA2 G2270R E2832K S2984L BRCA1 E438K S186F
20	72	4	360	NO	IVa	15	R1	NO	Spanish	NO				BRCA1 S1428*
21	70	5	420	YES	IIIc	20	R0	NO	Romanian	NO				TP53 Y236*	BRCA2 D1441N BRCA1 P1010S
22	68	5	400	YES	IIIc	18	R0	YES	Moroccan	NO				TP53 H193R	BRCA2 A2851L

FIGO stage: International Federatio of Gynaecology and Obstetrics staging system. PCI: Peritoneal carcinomatosis index. Cytoreductive Surgery: R0 No residual tumour, R1: Residual tumour less than 1 cm. + means Yes; * is only a variation of the gene.