Figure 6.

Rescue of endothelial cell metabolism by pericyte-derived mitochondria. Mitochondrial intact (Sol) or mitochondria-depleted (EtBr) endothelial cells were cocultured with pericytes (+PC) in the absence and presence of 19,20-DHDP for 36 h. Intermediates of the TCA cycle, asparagine, and glutamine metabolism were measured by LC-MS/MS; n = six independent cell batches (one-way ANOVA and Tukey’s multiple comparisons test). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. ACO: aconitase, ASNS: asparagine synthetase, CS: citrate synthase, FH: fumarate hydratase, GLS: glutaminase, GLUD: glutamate dehydrogenase, IDH: isocitrate dehydrogenase, LDH: lactate dehydrogenase, PDH: pyruvate dehydrogenase, SDH: succinate dehydrogenase, SUCLA: succinate-CoA ligase.