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. 2024 Sep 3;13(17):1478. doi: 10.3390/cells13171478

Figure 1.

Figure 1

Layout of the trial with neoadjuvant intratumoral ac-PD1 and CPMV/ac-PD1 injections. Before treatment, patient evaluation included the collection of a blood sample, thoracic radiographs, tumor measurements, QOL evaluation, and collection of an FNA. During a four-week treatment period, three dogs (P1–P3) received IT acPD-1 weekly and three dogs (P4–P6) received IT CPMV (D0) and, two days later, IT acPD-1 (D2). Three dogs (P1, P5, and P6) were treated further after D29 with CPMV/acPD-1 as a single weekly IT injection for 9 to 11 weeks.