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. 2024 Sep 3;13(17):1478. doi: 10.3390/cells13171478

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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acPD-1 and CPMV/acPD-1 treatments are associated with tumor control. Weekly acPD-1 as monotherapy (patients P1-P3; purple arrows; (A)) or CPMV (light green arrows in (C)) plus acPD-1 (purple arrows in (C)) was administered for four weeks to patients P4-P6; in P5, tumors P5.1 and P5.2 were treated. Starting on D29, long-term weekly IT CPMV/acPD-1 treatment ((E); dark green arrows) was administered to target tumors in patients P1, P6, and P5 (P5.1 and P52 were treated). The %TGI (relative to D0) in (B,D,F) indicates the SD in the dotted areas (−30 to 20), above 20% indicates PD, and below −30% indicates a partial response.